Studies On Cellulite

CELLULITE STUDIES

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The best anticellulite treatments and products to use now.

Ninety percent of women have cellulite -- regardless of shape, size or age. It appears when a collection of fat cells gets trapped in the connective tissue below the skin, causing its surface to pucker. Here, the scoop on what you can do to tackle the orange-peel effect.

Cellulite Treatments

The treatment	How it's supposed to work	Reported results	The details
Lipostabil injections ($1,000 and up per session)	• An enzyme called phosphadidyl choline (a.k.a. Lipostabil) is injected into fatty areas, like the butt and thighs, where it is said to break down and dissolve fat, slimming and smoothing the skin.	• There have been no published studies using the enzyme on the butt and thigh areas. There is, however, anecdotal evidence of its success in South America, where the treatment is popular.	• According to Steven Victor, M.D., a New York City cosmetic dermatologist, most patients require up to six sessions to see results.
CelluFite™ Spray And Cream ($35 Per Bottle)	• An oral spray is used as directed to target stubborn cellulite net fibers and help diminish bulges in problem areas such as the butt and thighs, where it is said to break down and dissolve fat, slimming and smoothing the skin.	• There have been no published studies using CelluFite™ on the butt and thigh areas. There is, however, anecdotal evidence of its success in South America, where the treatment is popular.	• According to Sharp Labs Inc., a research and development facility, most use for up to 2-4 months to see results.
Endermologie ($80 to $100 per session)	• A machine with large rollers (made by a company called LPG) massages the skin to break up fat. It has been FDA-approved for the temporary reduction of the appearance of cellulite.	• In a one-year clinical-outcome-study update published in the Aesthetic Plastic Surgery journal in 1998, 90 percent of participants reported an improvement in areas plagued by cellulite.	• The sensation of the rolling machines is similar to deep-tissue massage. Temporary bruising may occur. You will need 14 sessions (two per week) to see results that could last for many months.
Mesotherapy ($2,500 for 10 sessions and a consultation)	• A solution containing chemical and plant agents, as well as an anesthetic, is injected into dimpled areas. It is said to break down fat and block the production of new fat cells in the mesoderm layer of skin.	• No independent U.S. studies exist. But Marion Shapiro, D.O., director of Mesotherapy Associates PC in West Orange, NJ, says most of her female patients lose about two inches after four treatments.	• The injections are said to be painless. After the fat is treated, it is excreted in urine. You will need a minimum of 10 treatments, one per week, to see results. Maintenance shots may be required.
Ionithermie (an average of $125 per session)	• Two kinds of electrical stimuli, plus algae, conductive clay and special skin products developed in France (where Ionithermie was created) are used together to disperse cellulite.	• In a recent independent study conducted in France, the lead physician, Corinne Guibaud, M.D., said: "After 10 sessions, all subjects noticed a visible improvement in the 'orange peel' texture of the skin."	• A clay body mask and electrodes are applied. The electrodes emit a current said to break down and drain toxins. You may see results after the first session. Maintenance treatments are required.
Micro-liposuction plus external ultrasound (around $4,000)	• Micro-liposuction (performed using small canulas, or tubes) helps extract fat, while the ultrasound can affect the fat underneath the skin, causing it to drape differently after treatment.	• "Although liposuction alone does not address cellulite per se, I have seen minor improvements with this combination," says Debra B. Luftman, M.D., a Beverly Hills dermatologist.	• Both procedures can be performed in the same visit but must be administered by a qualified liposuction doctor (to find one, go to www.aad.org). Expect five days of severe bruising.

Rollers And Cellulite Study

Endermologie, a technique of using a system of rollers and a vacuum device to manipulate the skin, may work to smooth cellulite, but it does not cause a reduction in fat or promote the growth of new blood vessels, a VUMC study shows.

"This study is the first scientific evidence that Endermologie does something," said Dr. R. Bruce Shack, professor and chair of Plastic Surgery, who conducted the study along with Lillian B. Nanney, Ph.D., professor of Plastic Surgery, and others in the department.

Anecdotal evidence from both Europe, where the Endermologie device was invented by a French company about 10 years ago, and the U.S. had indicated a lessening of the appearance of the "cottage-cheese-like" appearance on the skin of those who underwent a series of treatments. But there had been no scientific evidence of how this apparent effect was achieved.

The findings of the VUMC study, which were based on studies with Yucatan mini-pigs, were published in the November/December edition of the Aesthetic Surgery Journal.

"The pig has long been known to be the best model for human skin," Nanney said. "It doesn't have any fur, and it's relatively fat." The most commonly advanced theory about how Endermologie achieves its apparent effects was that the machine, which resembles a high-tech vacuum cleaner with rollers on the hose nozzle, broke up fat, which was excreted, and also led to the formation of new blood vessels.

"We found nothing of the kind," Shack said. "There was no evidence of fat metabolism or excretion, no decrease in the thickness of the subcutaneous tissue that we could measure, and there was no evidence of new blood vessels. "What we saw was an absolute and total surprise to all of us. There was the creation of collagen bands that run parallel to the surface of the skin."

Shack said the formation of these bands was more marked in the pigs who were treated more often, adding weight to the idea that the changes were the result of the Endermologie treatments. "We're convinced that this response we are seeing in the pigs is real, we just don't know what it means," he said. "If this collagen is deposited in the deep layers of the skin running parallel to the surface of the skin, as that collagen contracts, and if there has been a loosening of the fat-fascial interface, you could speculate that that might have a smoothing effect on the surface of the skin."

Dr. David Adcock, a research fellow in Plastic Surgery who worked with Shack and Nanney on the published study, noted that the skill of the machine's operator could have a great deal to do with the effectiveness of the treatment. "Nobody has done anything to measure the force that's exerted on the tissue," he said. "It's the kneading itself that generates the most force on the tissue."

Shack said future studies on both pigs and clinical studies on humans are being planned to investigate issues such as the role of the operator in the effectiveness of treatment, and how long effects of treatments last. Elsewhere, Endermologie is also being investigated for its possible use in treatment of burn scars and lymphedema.

Study Cellulite Supplements

Publication type: Clinical Trial; Randomized Controlled Trial This study investigated the effect of a herbal anticellulite pill on visible cellulite in the thighs. Sixty female volunteers took a herbal anticellulite pill or a herbal anticellulite pill plus supplements of conjugated linoleic acid for 60 days. The combination treatment had a beneficial effect in as many as 75% of the women. The appearance of the skin improved significantly, and thigh circumference was reduced by an average of 0.88 inch. Further investigation in a larger, longer placebo-controlled trial is warranted.

Study Cellulite Review

Publication type: Review; Review, Tutorial Cellulite affects 85-98% of post-pubertal females of all races. While not a pathologic condition, it remains an issue of cosmetic concern to a great number of individuals. Despite its high prevalence, there have been few scientific investigations into the physiology of cellulite. There have only been a few dozen peer-reviewed articles devoted to cellulite in the medical literature in the past 30 years. There is no definitive explanation for its presentation. This greatly complicates the ability to treat or improve it. The four leading hypotheses that purport to explain the physiology of cellulite include: sexually dimorphic skin architecture, altered connective tissue septae, vascular changes and inflammatory factors. Treatment modalities can be divided into four main categories: attenuation of aggravating factors, physical and mechanical methods, pharmacological agents and laser. There are no truly effective treatments for cellulite

Study Cellulite Creams

There is little knowledge of the ingredients of cellulite creams in the dermatological literature as many of these formulas contain several ingredients to protect the manufacturers formula from being copied. One good example of this is CelluFite™ which is one of the more popular cellulite creams available in magazines, tv, and also online. In the present study, the ingredients of cellulite creams, the frequency of their use and whether the ingredients have been reported to cause allergy were investigated. In the 32 products tested, 263 ingredients were used. On average each product contained 22 ingredients (range 4 to 31). Botanicals and emollients predominated; altogether 44 different botanicals and 39 different emollients were used in the 32 products. Caffeine, present in 14 products was the most common additive, apparently representing an "active" ingredient. In other respects the compositions of the products were similar to those of skin creams. All products contained fragrance. The creams were microbiologically pure. Concentrations of preservatives did not exceed limit values in the regulations. No formaldehyde was present (detection limit 10 ppm). The well-known allergens isothiazolinones or dibromoglutaronitril were declared only in a few products. In spite of the large number of substances used in cellulite creams, their safety seems acceptable for most users. Because, however, one fourth of the substances used have been shown to cause allergy, the risk of adverse effects should be taken into account when using cellulite creams.



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If you have cellulite, chances are you won't like it. It's important to remember, though, that almost everyone wishes that something about their body was a bit different. This is particularly true for teens whose bodies are going through all sorts of changes caused by puberty. Now there is hope through the hard work and dedication of Sharp Labs Inc. and "CelluFite"™!

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